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Prolyl endopeptidase FAP Antibodies
AND FAP ELISA kits, Prolyl endopeptidase FAP Proteins
Many biological assays use antibodies to detect Prolyl endopeptidase FAP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prolyl endopeptidase FAP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prolyl endopeptidase FAP antibodies...
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FAP Infographic by Boster Bio
All FAP Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1101
96 wells/kit, with removable strips.
Cat # EK1101
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA
$480
Cat # EKC1209
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1209
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00422-5
100 μg/vial
Cat # A00422-5
100 μg/vial
Human
$628
Cat # LS002191
100 µg
Cat # LS002191
100 µg
FAP Overview
Facts about Prolyl endopeptidase FAP.
Prolyl endopeptidase FAP (FAP)
Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in several cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate including alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721).
Have also dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones such as dipeptidyl peptidase would be the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817).
Gene Information
| Human | |
|---|---|
| Gene Name: | FAP |
| Uniprot: | Q12884 |
| Entrez: | 2191 |
Family
| Belongs to: |
|---|
| peptidase S9B family |
Alternative Names
170 kDa melanoma membrane-bound gelatinase; DKFZp686G13158; DPPIV; EC 3.4.21.-; FAP; FAPA; Fibroblast Activation Protein alpha; fibroblast activation protein, alpha; Integral membrane serine protease; Seprase; vibronectin
Molecular Weight
Mass (kDA):
87.713 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.2 |
| Sequence: | 2; NC_000002.12 (162170684..162243472, complement) |
Tissue Specificity
Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
Subcellular Localizations
[Prolyl endopeptidase FAP]: Cell surface. Cell membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, ruffle membrane; Single-pass type II membrane protein. Membrane; Single-pass type II membrane protein. Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocali
Diseases
- Adenomatous Polyposis Coli
- Polyposis
- Malignant Neoplasms
- Neoplasms
- Polyneuropathy
- Colorectal Cancer
- Adenoma
- Carcinoma
- Polyps
- Colorectal Neoplasms
- Amyloid Neuropathies, Familial
- Amyloidosis
Interacting Proteins
- GCG
- VIP
Pathways
- Fibroblast Activation
- Pathogenesis
- Localization
- Mismatch Repair
- Cell Proliferation
- Angiogenesis
- Amyloid Fibril Formation
- Wound Healing
- Cell Growth
- Cell Cycle
- Aging
- Secretion
- Methylation
PTMs
- Cleavage
- Phosphorylation
- Methylation
- Oxidation
- Reduction
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FAP
bosterbio.com/bosterbio-gene-info-cards/FAP
References
PMID: 7911242 by Scanlan M.J., et al. Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.
PMID: 9247085 by Goldstein L.A., et al. Molecular cloning of seprase: a serine integral membrane protease from human melanoma.
1 Publications of Boster Prolyl endopeptidase FAP Antibodies & ELISA Kits
- PubMed ID: 34049984, Jin X,Wei M,Wang S,Wang G,Lai Y,Shi Y,Zhang Y,Yang Z,Wang X.Detecting fibroblast...
*More publications can be found for each product on its corresponding product page